1-Benzylpiperazine → HCID 18352676, compound

HRID 429727Notes

Reaction equation

HRID 429727 reaction equation
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:15]=[CH:14][C:9]2[NH:10][C:11](=[O:13])[O:12][C:8]=2[CH:7]=1)=[O:5].[C:16]1([CH2:22][N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[O:13]=[C:11]1[NH:10][C:9]2[CH:14]=[CH:15][C:6]([C:4](=[O:5])[CH2:3][CH2:2][N:26]3[CH2:27][CH2:28][N:23]([CH2:22][C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH2:24][CH2:25]3)=[CH:7][C:8]=2[O:12]1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 117908766-(3-Chloropropanoyl)-1,3-benzoxazol-2(3H)-one

Product 1

HCID 18352676HCID 18352676, compoundYield 66.9%

Procedure

Using 0.6 g of 3-chloro-1-(2,3-dihydro-2-oxobenzoxazol-6-yl)-1-propanone and 0.47 g of 1-(phenylmethyl)piperazine, 0.65 g of the title compound was obtained as colorless crystals, m.p. >300° C., in the same manner as in Example 6.

Sources & evidence

ORD record
ord-6ac6846ca37641299656ea79da154d2d
Source dataset
uspto-grants-2001_11
Patent number
US06319916B1

Reaction notes

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