Hydrogen Peroxide → HCID 20705960, compound

Participants

Reaction Steps

To a solution of Compound 78 (1.2 g, 2.2 mmol) in THF (50 mL) cooled to −78° C. with a dry ice-acetone bath was added dropwise 30 percent H2O2 (10 mL), and the mixture was allowed to warm up to room temperature, and stirred for 1.5 hours at room temperature. The mixture was diluted with ether and successively washed with ice-cold saturated Na2S2O3, saturated NaHCO3, saturated NaCl, and water. The organic phase was dried over anhydrous Na2SO4 and concentrated to give a α:β (1:4) mixture of Compound 85 (1.36 g, 98 percent) as judged by 1H-NMR (CDCl3). This product was used for the next step without further purification.

Provenance & Evidence