Hydrochloric Acid → 3-(4-thiazolyl)-L-alanyl-L-proline benzyl ester hydrochloride

Participants

Reaction Steps

To a solution of the compound (30) (3 g, 6.528 mmol) in ethyl acetate (10 ml) was added a solution of 4N hydrogen chloride in ethyl acetate (33 ml) under ice-cooling and the resulting mixture was stirred for 3 h. To the reaction mixture was added diethyl ether and the precipitation which apl)eare(d was filtered off to give 2.77 g of compound (32). This compound was used in the next reaction without purification.

Provenance & Evidence