反应详情

Dissolve 5 g (21.5 mmol) of melatonin in 150 ml of dichloromethane. With stirring, add 3.41 g (84 mmol) of sodium hydroxide and 0.35 g (0.9 mmol) of tetrabutylammonium hydrogen sulphate. Cool the mixture in an ice-bath, and add 4.06 ml (31.5 mmol) of benzenesulphonyl chloride dropwise. After stirring overnight at room temperature, filter off the excess sodium hydroxide and the catalyst. Remove the solvent by evaporation in vacuo, and recrystallise the resulting solid.

1. temperatureCool the mixture in an ice-bath
2. stirringAfter stirring overnight at room temperature
3. filtrationfilter off the excess sodium hydroxide
4. customRemove the solvent
5. customby evaporation in vacuo
6. customrecrystallise the resulting solid