反应详情

Dissolve the compound obtained in Step A in 100 ml of methanol. Cool the mixture in an ice-bath. Add thionyl chloride dropwise and maintain the reaction mixture at that temperature for 20 minutes after the addition. Leave for 1 hour at room temperature with stirring. Remove the methanol by evaporation under reduced pressure, and recrystallise the resulting solid from a mixture of toluene/cyclohexane (4/1).

1. temperatureCool the mixture in an ice-bath
2. additionafter the addition
3. customLeave for 1 hour at room temperature
4. customRemove the methanol
5. customby evaporation under reduced pressure
6. customrecrystallise the resulting solid
7. additionfrom a mixture of toluene/cyclohexane (4/1)