Thionyl Chloride → 2-Thiophenecarbonyl chloride, 3-(difluoromethoxy)-
Reaction equation
[F:1][CH:2]([F:12])[O:3][C:4]1[CH:8]=[CH:7][S:6][C:5]=1[C:9](O)=[O:10].S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[F:1][CH:2]([F:12])[O:3][C:4]1[CH:8]=[CH:7][S:6][C:5]=1[C:9]([Cl:15])=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
At 80° C., a mixture of 4.2 g (0.022 mol) of 3-difluoromethoxy-thiophene-2-carboxylic acid in 45 ml of toluene is admixed with 3.1 g (0.026 mol) of thionyl chloride. After the addition has ended, the reaction mixture is heated to 90° C. and stirred at this temperature for another 2 hours. The reaction mixture is subsequently concentrated under reduced pressure at 60° C. This gives 4.6 (98.3% of theory) of 3-difluoromethoxy-thiophene-2-carbonyl chloride in the form of an oil.
Workup
- additionAfter the addition
- concentrationThe reaction mixture is subsequently concentrated under reduced pressure at 60° C
Sources & evidence
- ORD record
- ord-a789cf7cac9e40c784f84c4002c42c0f
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06319940B1
Reaction notes
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