反应详情

A mixture of N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-[1-(benzyloxycarbonyl)piperidin-4-ylcarbonyl]amine (3.5 grams, 8.3 mmole) and 10% palladium on carbon (0.7 grams) in ethanol (40 ml) was hydrogenated at 22° C. and 50 p.s.i. for 2.5 hours. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to leave N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(piperidin-4-ylcarbonyl)amine as a syrup (2.11 grams, 84%), M+H 305.

1. customwas hydrogenated at 22° C.
2. customThe catalyst was removed by filtration
3. concentrationthe filtrate was concentrated under reduced pressure