反应详情

To a solution of N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine (0.23 grams, 0.79 mmole) in ethyl ether (10 ml) was added methyl isocyanate (0.2 ml, 3.4 mmole). After 1.0 hour at 22° C., the solution was concentrated under reduced pressure and the residue was recrystallized from ethyl ether/hexane to give N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-[1-(methylaminocarbonyl)piperidin-4-ylmethyl]amine (0.249 grams, 91%) m.p. 97-98° C.

1. concentrationthe solution was concentrated under reduced pressure
2. customthe residue was recrystallized from ethyl ether/hexane