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HRID429836

反应详情

EQUATION

反应方程式

HRID 429836 的结构方程式

REACTANTS

反应物

2
结构：O=P(O)(O)O
HCID1004

Phosphoric acid

H3O4P

结构：CCN(CC1CCN(S(C)(=O)=O)CC1)[C@@H](C)Cc1ccc2c(c1)CCO2
HCID10927016

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CC1CCN(S(C)(=O)=O)CC1)[C@@H](C)Cc1ccc2c(c1)CCO2.O=P(O)(O)O
HCID20706302

未命名化合物

收率 97%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

(S)-N-[2-(2,3,-Dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine (0.4 grams, 1.05 mmole) was dissolved in (10 ml) hot 10% aqueous ethanol. To this solution was added 85% phosphoric acid (0.122 grams, 1.06 mmole). The solution was stored at 22° C. for 16 hours. The deposited crystals were collected and dried in vacuo at 70° C. to give (S)-N-[2-(2,3,-dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine phosphate (0.454 grams, 97%), m.p. 209-210° C.

WORKUP

后处理

  1. customThe deposited crystals were collected
  2. customdried in vacuo at 70° C.