HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 3024740, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-[4-(2-chloropropanoyl)phenyl]acetamide | HCID 322933 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 3024740 | HCID 3024740 | 89.3% |
Reaction Steps
A mixture of N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide (0.19 mol), N-methyl-methanamine hydrochloride (1:1)(0.38 mol) and K2CO3 (78.8 g) in CH3CN (1400 ml) was stirred and refluxed for 12 hours. The mixture was cooled, poured into water and extracted with CH2Cl2. The organic layer was dried, filtered and the solvent was evaporated, yielding 39.77 g (89%) of (±)-N-[4-[2-(dimethylamino)-1-oxopropyl]phenyl]-acetamide (interm. 9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06319939B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-04c3c912b628438dbdd996fdbfa111a5 |
| Source note | uspto-grants-2001_11 |