Hydrochloric Acid → HCID 15552388, compound

Participants

Reaction Steps

To a stirred solution of methyl 4-[(E)-[5,6-dihydro-5,5-dimethyl-8-[(E)-phenylethenyl]-2-naphthalenyl]ethenyl]benzoate (0.206 g, 0.49 mmol) in a mixture of tetrahydrofuran/ethanol (1:1, 2 mL) was added aqueous sodium hydroxide (5N, 0.98 mL, 4.90 mmol). The mixture was stirred overnight. Hydrochloric acid 1N was then added to precipitate the acid and ≈half of the volume of the solvents was evaporated. The white solid was filtered and washed with water. The solid was then dissolved in dichloromethane/ethanol, filtered and recrystallized from this mixture by evaporating the solvents. The title compound was obtained (0.149 g, 75%) as a white solid.

Provenance & Evidence