反应详情

To a solution of trans-3,4-difluorocinnamic acid (10 g,54 mmol) in 300 mL methanol was added concentrated sulfuric acid (2 mL). The solution was stirred 48 h at ambient temperature and then concentrated in vacuo. The residue was taken up in ethyl acetate (500 mL) and washed with saturated sodium bicarbonate (2×100 mL), brine (1×100 mL), dried with magnesium sulfate, and concentrated in vacuo to provide trans-3,4-difluorocinnamic acid methyl ester as a white solid.

1. concentrationconcentrated in vacuo
2. washwashed with saturated sodium bicarbonate (2×100 mL), brine (1×100 mL)
3. dry with materialdried with magnesium sulfate
4. concentrationconcentrated in vacuo