Phosphorus tribromide → 3-Cyclobutylbenzyl bromide

Participants

Reaction Steps

According to example 17, 1.29 g of 3-cyclobutylbenzyl alcohol was treated with 0.26 mL of PBr3 in 15 mL of anhydrous CH2Cl2 to afford 1.69 g of crude product (92% pure by 1H-NMR). This material was purified by flash chromatography on 65 g of silica gel hexane) to afford 1.59 g (89%) of 3-cyclobutyl benzyl bromide as a clear liquid.

Provenance & Evidence