HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(2-pyridinyl)-1-Piperidinepropanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-[4-(2-Pyridyl)piperidin-1-yl]propylamine l-tartrate salt | HCID 70151200 | — |
| Product | 4-(2-pyridinyl)-1-Piperidinepropanamine | HCID 10176815 | — |
Reaction Steps
3-[4-(2-pyridyl)piperidin-1-yl]propylamine L-tartrate salt, (7), (1120 g, 3.0 mol) was treated with 5M NaOH (5.7 L, 28.6 mol). The suspension was extracted with isopropyl acetate (3×18 L). The combined extracts were concentrated to afford 3-[4-(2-pyridyl)-piperidin-1-yl]propylamine, (6), as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06320049B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-1bf3103c9ce04e95aba3cb58e74e6f54 |
| Source note | uspto-grants-2001_11 |