反应详情

温度

100 °C

400 g of dimethyl sulfoxide and a solution of 37 g of potassium hydroxide (0.66 mol) in 400 ml:of water are warmed to 100° C. in a three-neck flask fitted with reflux condenser and stirrer. 163 g of the 5-fluoro-2-nitrophenyl benzyl ether prepared as described in Example 1 (0.66 mol) are then added in portions, and the mixture is then heated at 100° C. for 8 hours. After the mixture has been cooled to room temperature, a colorless reaction product precipitates; this is filtered off, washed with water and dried. The reaction product is then recrystallized from ethyl acetate.

1. customfitted
2. temperaturewith reflux condenser and stirrer
3. additionare then added in portions
4. temperatureAfter the mixture has been cooled to room temperature
5. customa colorless reaction product precipitates
6. filtrationthis is filtered off
7. washwashed with water
8. customdried
9. customThe reaction product is then recrystallized from ethyl acetate