Triethylamine → N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonamide

Participants

Reaction Steps

To a solution of (1-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol (0.096 mmol, 30 mg) and triethylamine (0.193 mmol, 0.027 mL, 19.50 mg) in DCM (0.9 mL) was added 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride (0.096 mmol, 23.96 mg) and the whole stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and the residue purified by RP-HPLC to give a clear film (12.0 mg, 0.023 mmol, 23.8%). MS (ESI): m/z [M+H]+ 524.0.

Provenance & Evidence