Isobutyric Acid → N-(5-((4-(Hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)isobutyramide

참여 물질

반응 단계

To a solution of (1-((1-amino-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol (0.096 mmol, 30 mg), isobutyric acid (0.096 mmol, 8.94 μL 8.49 mg), triethylamine (0.193 mmol, 0.027 ml, 19.50 mg) and HOBt (0.096 mmol, 13.02 mg) in DMF (0.8 mL) was added EDCI/WSC (0.096 mmol, 18.47 mg). The whole was stirred at room temperature overnight before the reaction mixture was quenched by the addition of MeOH (100 μL) before being purified by prep HPLC to give a white solid (10.8 mg, 0.028 mmol, 29.4%). MS (ESI): m/z [M+H]+ 382.2

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