反应详情

A solution of 8-benzyloxy-3-(2-propynyloxymethyl)-2-methylimidazo[1,2-a]pyridine hydrochloride (35.5 g) in hot water (700 ml) was neutralized with aqueous sodium hydroxide solution and extracted with methylene chloride. The extract was washed with water, dried over magnesium sulfate, treated with activated charcoal, and evaporated in vacuo. The residual solid was recrystallized from a mixture of methylene chloride and n-hexane to give 8-benzyloxy-3-(2-propynyloxymethyl)-2-methylimidazo[1,2-a]pyridine (26.03 g).

1. extractionextracted with methylene chloride
2. washThe extract was washed with water
3. dry with materialdried over magnesium sulfate
4. additiontreated with activated charcoal
5. customevaporated in vacuo
6. customThe residual solid was recrystallized from a mixture of methylene chloride and n-hexane