3-Chloro-2-methoxybenzoic acid methyl ester → 4-(3-Chloro-2-methoxyphenyl)-2-oxo-valeric acid

HRID 430464Notes

Reaction equation

HRID 430464 reaction equation
COC(=O)C1C=CC=C([Cl:10])C=1OC.I[C:15]1[CH:20]=[CH:19][C:18]([C:21](C)([CH3:28])[CH2:22][C:23](=[O:27])[C:24]([OH:26])=[O:25])=[C:17]([O:30][CH3:31])[CH:16]=1>>[Cl:10][C:16]1[C:17]([O:30][CH3:31])=[C:18]([CH:21]([CH3:28])[CH2:22][C:23](=[O:27])[C:24]([OH:26])=[O:25])[CH:19]=[CH:20][CH:15]=1

Participants

3

Reactant 2

HCID 148770593-Chloro-2-methoxybenzoic acid methyl esterHCID 185511904-(4-Iodo-2-methoxyphenyl)-4-methyl-2-oxovaleric acid

Product 1

HCID 183506314-(3-Chloro-2-methoxyphenyl)-2-oxo-valeric acid

Procedure

This ester is reacted analogously to the process that is described for 4-(4-iodo-2-methoxyphenyl)-4-methyl-2-oxo-valeric acid. 8 g of the title compound is obtained as a light yellow oil.

Sources & evidence

ORD record
ord-bc620bb2e8ca461a8a0fade8d4cab407
Source dataset
uspto-grants-2001_11
Patent number
US06323199B1

Reaction notes

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