HuagongsheHuagongshe Chemistry Print Report · For research reference only
2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- → 6-[2-Hydroxy-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethyl-pentylamino]-4-methyl-2,3-benzoxazin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Reactant | 6-amino-4-methyl-2,3-benzoxazin-1-one | HCID 11182936 | — |
| Reactant | 2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane | HCID 16099239 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-[2-Hydroxy-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethyl-pentylamino]-4-methyl-2,3-benzoxazin-1-one | HCID 15463551 | — |
Reaction Steps
584 mg of 2-[2-(5-fluoro-2-methoxyphenyl)-2-methyl-propyl]-2-trifluoromethyl-oxiran, 282 mg of 6-amino-4-methyl-2,3-benzoxazin-1-one and 1 ml of 1,3-dimethyl-3,4,5,6-tetrahydro-2[1H]-pyrimidinone are heated to 120° C. for 6 hours. After 1 ml of tetrahydrofuran is added, it is chromatographed on silica gel, and the title compound is eluted with hexane/ethyl acetate/tetrahydrofuran (55:40:5), flash point 178-179° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06323199B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-e2ffd892c314470c93c2f2555b3d26d4 |
| Source note | uspto-grants-2001_11 |