N-bromobutanimide → HCID 18350648, compound

Participants

Reaction Steps

55 mg of (−)-5-[4-(5-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]-phthalide is mixed under nitrogen in 1 ml of dimethylformamide at 2° C. with 18 mg of N-bromosuccinimide. After 2 hours at this temperature, it is diluted with 20 ml of ethyl acetate, extracted with water, and the organic phase is dried (Na2SO4) and concentrated by evaporation. With chromatography on silica gel, the title compound in crystalline form is eluted with hexane/ethyl acetate (4:1), flash point 228-232° C.

Provenance & Evidence