HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 430489Generated: October 29, 2026
3-Bromoaniline → N-(3-Bromophenyl)-6-nitroquinazolin-4-amine
https://huagongshe.com/reaction/430489
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromoaniline | HCID 11562 | — |
| Reactant | N'-(2-cyano-4-nitrophenyl)-N,N-dimethylmethanimidamide | HCID 10900084 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-(3-Bromophenyl)-6-nitroquinazolin-4-amine | HCID 5328041 | — |
Reaction Steps
A solution of 23.74 ml of 3-bromo aniline and 40.5 g N′-(2-cyano-4-nitrophenyl)-N,N-dimethylformamidine in 100 ml of glacial acetic acid was stirred and heated in an oil bath at 148° C. for 1.5 hours. On cooling, filtration of the resulting solid gives a quantitative yield of N-(3-bromophenyl)-6-nitro4-quinazolinamine: mp=267-270° C.; mass spectrum (m/e): 345.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06323209B1 |
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| Source dataset | uspto-grants-2001_11 |
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| ORD ID | ord-980d4ea179ab438baa1daf5c11db6fa7 |
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| Source note | uspto-grants-2001_11 |
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