HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-Acetamidopyrazine-2-carboxylic acid o-toluamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-Aminopyrazine-2carboxylic acid o-toluamide | HCID 69709687 | — |
| Product | 3-Acetamidopyrazine-2-carboxylic acid o-toluamide | HCID 69709772 | 76% |
Reaction Steps
A mixture of 3-aminopyrazine-2carboxylic acid o-toluamide (1.0 g, 4.39 mmol) and acetic anhydride (12 mL) was refluxed 2 hours. The solvent was removed and the residue was triturated with hot ethyl acetate. The ethyl acetate slurry was cooled and the product was collected and rinsed with ether to afford 0.893 g (76%) of 3-acetamidopyrazine-2-carboxylic acid o-toluamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06323208B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-00264fb35d554e869a4f49c0ccb5dfa0 |
| Source note | uspto-grants-2001_11 |