反应详情

温度

100 °C

under a nitrogen atmosphere, 3-fluoroaniline (50.0 g, 0.45 mol) and diethyl ethoxymethylmalonate (91 mL, 0.45 mol) were combined and heated at 100° C. for 3 hours. The reaction was allowed to cool to ambient temperature and it solidified. Dowtherm A (200 mL) was added and the reaction mixture was heated at 240° C. for 4 hours. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, washed with hexane and then dried in a vacuum oven to provide 71.5 g of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate.

1. temperatureto cool to ambient temperature
2. temperaturethe reaction mixture was heated at 240° C. for 4 hours
3. temperatureto cool to ambient temperature
4. customThe resulting precipitate was isolated by filtration
5. washwashed with hexane
6. customdried in a vacuum oven