反应详情

7-Chloro-4-hydroxyquinoline (35 g, 0.195 mol; available from Aldrich, Milwaukee, Wis.) and nitric acid (350 mL of 70%) were combined and heated at reflux for 75 minutes. The reaction mixture was poured over ice while still hot. The resulting bright yellow precipitate was isolated by filtration and then washed 3 times with boiling ethyl acetate to provide 17.3 g of 7-chloro-3-nitro-4-hydroxyquinoline as a pale yellow solid.

1. temperatureheated
2. temperatureat reflux for 75 minutes
3. additionThe reaction mixture was poured over ice while still hot
4. customThe resulting bright yellow precipitate was isolated by filtration
5. washwashed 3 times with boiling ethyl acetate