Pradofloxacin → Pradofloxacin Hydrochloride

HRID 430582Notes

Reaction equation

HRID 430582 reaction equation
[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][NH:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2].[ClH:30].O1CCOCC1>>[ClH:30].[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][NH:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:14][CH2:15]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2]

Participants

3

Reactant 2

HCID 9802884PradofloxacinHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 9802883Pradofloxacin Hydrochloride

Procedure

5.00 g (12.6 mmol) of 8-cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are stirred in 95 ml of 4 N hydrochloric acid/dioxane (1:1) at 60° C. for two hours. The reaction mixture is concentrated in vacuo and the residue is recrystallized from ethanol.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-f1aec99bb97442eda992b1bb1e745d06
Source dataset
uspto-grants-2001_11
Patent number
US06323213B1

Reaction notes

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