HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-bromo-2,4,5-trifluorobenzoate → Methyl 3-cyano-2,4,5-trifluoro-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-bromo-2,4,5-trifluorobenzoate | HCID 18459836 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 3-cyano-2,4,5-trifluoro-benzoate | HCID 18417526 | 61.8% |
Reaction Steps
A mixture of 269 g of methyl 3-bromo-2,4,5-trifluorobenzoate, 108 g of copper(I) cyanide and 400 ml of dimethylformamide is heated under reflux for 5 hours. All volatile components are distilled off in vacuo. Fractional distillation of the resulting mixture gives 133 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06323213B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-88c4248f374b4852b39ecf0afe36429e |
| Source note | uspto-grants-2001_11 |