HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18351343, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 4-(Aminomethyl)-1-benzylpiperidin-4-ol | HCID 10421026 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18351343 | HCID 18351343 | — |
Reaction Steps
A solution of 14.75 g of ethyl chloroformate in 125 ml of dichloromethane is added, at 0° C., to a solution of 30 g of 1-benzyl-4-aminomethyl-piperidin-4-ol and 13.8 g of triethylamine in 250 ml of dichloromethane. After 10 minutes' contact, the reaction mixture is washed with 0.1N sodium hydroxide solution and then dried over MgSO4. Concentration under reduced pressure enables the expected product to be isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06323217B2 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-5a9f4d55fb364f7e8fb701b31aeeadcf |
| Source note | uspto-grants-2001_11 |