Sodium borohydride → HCID 70199065, compound

HRID 430612Notes

Reaction equation

HRID 430612 reaction equation
[BH4-].[Na+].[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5]([C:12](=[O:28])[CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:16][CH2:15]2)=[CH:4]1>C(O)C>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5]([CH:12]([OH:28])[CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:24])([CH3:26])[CH3:25])[CH2:18][CH2:19]2)=[CH:4]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18351309HCID 18351309, compound

Product 1

HCID 70199065HCID 70199065, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.2 g of sodium borohydride are added in portions to a solution of 7.7 g of the product obtained in Step A in 100 ml of ethanol. After 1 hour's reaction, the solution is evaporated, taken up in water, extracted with ethyl acetate, dried and then concentrated under reduced pressure. Chromatography over silica gel (dichloromethane/ethanol: 95/5) enables the expected product to be isolated.

Workup

  1. customAfter 1 hour's reaction
  2. customthe solution is evaporated
  3. extractionextracted with ethyl acetate
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customto be isolated

Sources & evidence

ORD record
ord-50f2c605ce0446fb88f8ec93042ac297
Source dataset
uspto-grants-2001_11
Patent number
US06323217B2

Reaction notes

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