Hydrochloric Acid → 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine hydrochloride

Participants

Reaction Steps

A mixture of [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester (Step 26.2) (0.75 g, 2.8 mmol) and a 4 N solution of HCl in dioxane (20 mL) was stirred for 72 h at rt and concentrated to afford 660 mg of the title compound as a white solid: ESI-MS: 221.1 [M+H]+; tR=0.80 min (System 1).

Provenance & Evidence