HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 18183111, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | HCID 18183141 | HCID 18183141 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18183111 | HCID 18183111 | 82.3% |
Reaction Steps
900 mg of 8-methyl-5-(4-nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine is mixed in 10 ml of dimethylformamide with 441 mg of N-bromosuccinimide and stirred for 1.5 hours at room temperature. After dilution with 40 ml of water, the precipitated product is suctioned off, and 900 mg of 9-bromo-8-methyl-5-(4-nitrophenyl)-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06323197B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-13ea4203f4434203a8b5e1366c81debf |
| Source note | uspto-grants-2001_11 |