5-Isocyanato-1,2,3-trimethoxybenzene → HCID 20613235, compound

HRID 430701Notes

Reaction equation

HRID 430701 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:13]=[C:14]=[O:15])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].ClC1C=C(C=CC=1Cl)CC1CCN(C[C@H](N)C(C)C)CC1.[Cl:37][C:38]1[CH:39]=[C:40]([CH:55]=[CH:56][C:57]=1[Cl:58])[CH2:41][CH:42]1[CH2:47][CH2:46][N:45]([CH2:48][C@H:49]([NH2:54])[C:50]([CH3:53])([CH3:52])[CH3:51])[CH2:44][CH2:43]1>>[Cl:37][C:38]1[CH:39]=[C:40]([CH:55]=[CH:56][C:57]=1[Cl:58])[CH2:41][CH:42]1[CH2:43][CH2:44][N:45]([CH2:48][C@H:49]([NH:54][C:14]([NH:13][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=2)=[O:15])[C:50]([CH3:53])([CH3:52])[CH3:51])[CH2:46][CH2:47]1

Participants

4

Reactant 3

HCID 5177665-Isocyanato-1,2,3-trimethoxybenzeneHCID 18346048HCID 18346048, compoundHCID 22943538HCID 22943538, compound

Product 1

HCID 20613235HCID 20613235, compound

Procedure

Proceeding as described in Example 13 above, but substituting 3-methoxyphenylisocyanate with 3,4,5-trimethoxyphenylisocyanate and 1-(R)-[4-(3,4-dichlorobenzyl)-piperidin-1-ylmethyl]-2-methylpropylamine with 1-(R)-[4-(3,4-dichlorobenzyl)-piperidin-1-ylmethyl]-2,2-dimethylpropylamine gave 1-{1-(R)-[4-(3,4-dichlorobenzyl)-piperidin-1-ylmethyl]-2,2-dimethylpropyl}-3-(3,4,5-trimethoxyphenyl)urea.

Sources & evidence

ORD record
ord-99fbd4dd6882405582819aa78f035a4a
Source dataset
uspto-grants-2001_11
Patent number
US06323223B1

Reaction notes

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