Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5,7-Di-tert-butyl-3-hydroxy-2-benzofuranone | HCID 6850821 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 18352049 | HCID 18352049 | 36% |
Reaction Steps
12.9 g (0.052 mol) of 5,7-di-tert-butyl-3-hydroxybenzofuranone are dissolved in 50 ml of toluene and treated with 2.9 ml (0.052 mol) of bromine at 30° C. The mixture is subsequently stirred at 60° C. for 30 minutes. The solvent is distilled off by means of a rotary evaporator. 1 g of the crude product is purified by flash chromatography over silica gel (Merck Silicagel 60, 70-230 mesh ASTM; mobile phase: 1:1 hexane/dichloromethane) to leave 0.26 g (36% of theory) of 5,7-di-tert-butyl-3-bromobenzofuranone (XLVII).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06323267B1 |
|---|
| Source dataset | uspto-grants-2001_11 |
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| ORD ID | ord-413ae0556e414238b44dcdd389441e89 |
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| Source note | uspto-grants-2001_11 |
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