Water → HCID 18351618, compound

Participants

Reaction Conditions

Reaction Steps

(3-(2-(diphenylmethyl)thioethyl)benzofuran-7-yloxy)acetic acid (126 mg) was dissolved in dichloromethane (2 ml) and the obtained solution was cooled to 0° C. To this solution, m-chloroperbenzoic acid (143 mg) was added and the resulting mixture was stirred for 2 hours. The reaction solution was poured into water layer (30 ml) and the resultant was extracted twice with ethyl acetate (20 ml). The organic layers were combined and washed with saturated aqueous sodium thiosulfate solution and with saturated brine, followed by drying over sodium sulfate. After removing the sodium sulfate by filtration, the solvent was removed under reduced pressure and the residue was purified by column chromatography (solvent: hexane/ethyl acetate=1/2+5% acetic acid) using silica gel to obtain the desired compound (97 mg, yield: 72%).

Provenance & Evidence