Sodium Hydroxide → HCID 18351695, compound

Participants

Reaction Steps

Methyl (1-(2-(N-(diphenylmethyl)amino)ethyl)indole-4-yloxy)acetate (99 mg) was dissolved in a mixed solvent of ethanol (5 ml) and THF (2 ml), and the obtained solution was stirred at room temperature. To this solution, 1N aqueous sodium hydroxide solution was added and the resulting solution was stirred at room temperature. After confirming vanishment of the materials, the solvent was removed under reduced pressure. Water (5 ml) was added to the obtained residue and 1N hydrochloric acid was added to the mixture to neutralize the same. The precipitated solids were collected by centrifugation and washed twice with water and twice with methanol. The solids were dried under reduced pressure to obtain the desired compound (58 mg, yield: 61%)

Provenance & Evidence