反应详情

A solution of 2-mercapto-1-[2-oxo-2-(2-pyridyl)ethyl]benzimidazole (1 g.) in polyphosphoric acid was heated at 140° C. for 1 hour. The solution was neutralised with Na2CO3 solution and extracted into EtOAc (700 ml). The extracts were dried (MgSO4) and evaporated to give a solid which was recrystallised from EtOAc/EtOH to give the title compound (0.35 g.) mp 222°-4° C.

1. extractionextracted into EtOAc (700 ml)
2. dry with materialThe extracts were dried (MgSO4)
3. customevaporated
4. customto give a solid which
5. customwas recrystallised from EtOAc/EtOH