Ammonium Chloride → HCID 20708402, compound

Participants

Reaction Steps

Under argon atmosphere, potassium t-butoxide (586 mg) and methyl bromoacetate (2.50 ml) were added to 1-(2-(diphenylmethoxy)ethyl)-4-hydroxyindoline (855 mg) in DMF (15 ml), and the obtained mixture was stirred at room temperature for 2 hours. To the reaction mixture, saturated aqueous ammonium chloride solution (5 ml) was added to stop the reaction and the resultant was extracted with ethyl acetate. The obtained organic layer was washed and dried over sodium sulfate. After removing solids by filtration, the solvent was removed under reduced pressure and the obtained crude product was purified by silica gel column chromatography to obtain the desired compound (571 mg, yield: 55%)

Provenance & Evidence