Formaldehyde → HCID 70211536, compound

HRID 430856Notes

Reaction equation

HRID 430856 reaction equation
[C:1]1([CH:7]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9](=[O:14])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:15].[CH3:16][NH:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH2:26]=O>>[ClH:15].[CH3:16][N:17]([CH2:26][CH:10]1[CH2:11][CH2:12][CH2:13][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][C:9]1=[O:14])[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 77742Phenethylamine, N-methyl-, hydrochlorideHCID 1129841674395-08-7

Product 1

HCID 70211536HCID 70211536, compound

Procedure

A mixture of 2.77g of 3-phenylcycloheptanone, 2.52 g of methylphenethylamine hydrochloride and 1.23 ml of an aqueous formaldehyde solution (36%) were heated on a water bath for 2 hours under vigorous stirring and with the introduction of nitrogen. The mixture was then evaporated under vacuum, the residue was extracted 3 times with diethylether/n-hexane=1/1 and dried under vacuum. 5.4 g of the crude title compound were then obtained.

Workup

  1. temperaturewere heated on a water bath for 2 hours
  2. customThe mixture was then evaporated under vacuum
  3. extractionthe residue was extracted 3 times with diethylether/n-hexane=1/1
  4. customdried under vacuum

Sources & evidence

ORD record
ord-0ba4523b9de3424eac86a0d6b115d1f3
Source dataset
uspto-grants-2001_11
Patent number
US06323369B1

Reaction notes

Loading…