6-(4-Methylpiperazin-1-yl)pyridin-3-amine → 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-Pyridin-3-yl]-amide

HRID 43087Notes

Reaction equation

HRID 43087 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.C(N1CCN(C2C=C(N[C:30]([C:32]3[C:33]4[N:34]=[CH:35][CH:36]=[N:37][C:38]=4[C:39]([C:42]4[C:51]5[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=5)[CH:45]=[N:44][CH:43]=4)=[CH:40][CH:41]=3)=[O:31])C=CC=2)CC1)C>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH:14][C:30]([C:32]3[C:33]4[N:34]=[CH:35][CH:36]=[N:37][C:38]=4[C:39]([C:42]4[C:51]5[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=5)[CH:45]=[N:44][CH:43]=4)=[CH:40][CH:41]=3)=[O:31])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 27633906-(4-Methylpiperazin-1-yl)pyridin-3-amineHCID 445156698-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide

Product 1

HCID 445156728-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-Pyridin-3-yl]-amide

Procedure

The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture for 20 h at it and using 6-(4-methylpiperazin-1-yl)-pyridin-3-ylamine (prepared as described in Example 33 but using N-methyl-piperazine in Step 33.2) and 8-isoquinolin-4-yl-quinoxaline-5-carboxylic acid (Example 52). Title compound: ESI-MS: 476.1 [M+H]+; tR=1.98 min (System 1).

Workup

  1. customThe title compound was prepared in analogy to the procedure

Sources & evidence

ORD record
ord-6125f11799174ce5b0bdb179f787ce9e
Source dataset
uspto-grants-2013_09
Patent number
US08536175B2

Reaction notes

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