Hydrochloric Acid → 3-[4-Cyano-3-methoxyphenyl]-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Participants

Reaction Steps

Sodium methanolate solution (2.8 g of a 30 percent strength solution in methanol) was added to a solution of 3-[4-cyano-3-nitrophenyl]-6-trifluoromethyl-1,2,3,4-tetrahydro-pyrimidine-2,4-dione (2.4 g) in 50 ml of anhydrous methanol. The reaction mixture was subsequently refluxed for 5 hours. After cooling, water (50 ml) was added first, followed by 10% strength aqueous hydrochloric acid to a pH of 3-4. The precipitate formed was subsequently separated off, washed with water and petroleum ether and dried. Yield: 1.1 g; m.p.: >230° C.

Provenance & Evidence