Potassium Cyanide → HCID 15334671, compound

Participants

Reaction Steps

Potassium cyanide (0.5 g) was added to a solution of 3-[2,4-difluoro-5-nitrophenyl]-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (2.5 g) in 50 ml of anhydrous dimethyl sulfoxide. The reaction mixture was subsequently stirred for 10 hours at room temperature, more potassium cyanide (0.16 g) being added after 5 hours. For working-up, most of the solvent was removed at 80° C. under a high vacuum. The residue was taken up in 150 ml of water, washed three times using in each case 30 ml of water, dried over sodium sulfate and concentrated. Chromatography on silica gel (dichloromethane as eluent) and crystallization using petroleum ether gave 1.2 g of the desired product; m.p.: 155-157° C. The following compounds of Table 3 were prepared in a similar manner:

Provenance & Evidence