Benzylamine → HCID 10207861, compound

HRID 430950Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:28]=[CH:27][C:8]([CH2:9][N:10]2[C:15](=[O:16])[N:14]([CH3:17])[C:13]3[CH:18]=[CH:19][C:20]([C:22]([OH:24])=O)=[CH:21][C:12]=3[S:11]2(=[O:26])=[O:25])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:29]([NH2:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:29]([NH:36][C:22]([C:20]1[CH:19]=[CH:18][C:13]2[N:14]([CH3:17])[C:15](=[O:16])[N:10]([CH2:9][C:8]3[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:28][CH:27]=3)[S:11](=[O:25])(=[O:26])[C:12]=2[CH:21]=1)=[O:24])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 69836637HCID 69836637, compound

Product 1

HCID 10207861HCID 10207861, compound

Procedure

2-(4-Methanesulfonyl-benzyl)-4-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-carboxylic acid was coupled with benzyl amine according to the procedure of Example 2 to give the title compound. 1H-NMR (CDCl3); δ 8.19 (s, 1H), 8.01 (d, 1H), 7.74 (d, 2H), 7.45 (d, 2H), 7.34 (m, 6H), 6.67 (bs, 1H), 4.62 (t, 2H), 3.76 (bs, 2H), 3.22 (s, 3H) and 2.98 (s, 3H) ppm. Anal. (C24H23N3O6S2.0.5C4H10O.0.66H2O) C,H,N. MS: M++1=514.1 Da

Sources & evidence

ORD record: ord-c60072afbf924c2480aa65e9f3de0b66
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06656932B2

Reaction notes

Loading…