Hydrochloric Acid → HCID 69867781, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.65 g 2-formylbenzoic acid in 5 ml ethanol and 5 ml 2 M sodium hydroxide solution was added to a solution of 1.46 g L-glutamine in 5 ml of a 2 M aqueous sodium hydroxide solution. After stirring for 1 h at 20° C., the mixture was cooled to 0° C. and 0.25 g sodium borohydride were added in portions over 15 min with vigorous stirring. After 90 min a further 0.33 g 2-formyl benzoic acid and 0.05 g sodium borohydride were added. After stirring for 16 h at 20° C., the reaction mixture was acidified with conc. hydrochloric acid to pH 2 and cooled to 0° C. The precipitate formed was separated off, washed with acetone and dried in vacuo. 0.87 g (31% of theoretical) of the title compound remained in the form of crystals, which melted at 132-133° C.

Provenance & Evidence