HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 430957Generated: October 30, 2026
Aniline → 3-Phenylaminomethyl piperidine-2,6-dione
https://huagongshe.com/reaction/430957
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Methylidenepiperidine-2,6-dione | HCID 359404 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Phenylaminomethyl piperidine-2,6-dione | HCID 18762657 | — |
Reaction Steps
30 ml absolute triethylamine and 2.75 ml freshly distilled aniline were added to a solution of 1.25 g 3-methylene piperidine-2,6-dione (M. J. Wanner and G. -J. Koomen, Tetrahedron Lett. 1992, 33, 1513-1516) in 100 ml acetonitrile and the mixture was stirred for 16 h at 80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06656937B2 |
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| Source dataset | uspto-grants-2003_12 |
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| ORD ID | ord-e8e2a509f94d46bb9dc96a4cb619f9ba |
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| Source note | uspto-grants-2003_12 |
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