HCID 10760311, compound → 8-{[(2s)-8-Methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}-3-(2-methoxyphenyl)-8-azabicyclo[3.2.1]octan-3-ol

HRID 431001Notes

Reaction equation

HRID 431001 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1([OH:17])[CH2:15][CH:14]2[NH:16][CH:11]([CH2:12][CH2:13]2)[CH2:10]1.[CH3:18][O:19][C:20]1[C:25]2[O:26][C@H:27]([CH2:30]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:28][O:29][C:24]=2[CH:23]=[CH:22][CH:21]=1>>[CH3:18][O:19][C:20]1[C:25]2[O:26][C@@H:27]([CH2:30][N:16]3[CH:11]4[CH2:12][CH2:13][CH:14]3[CH2:15][C:9]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[O:2][CH3:1])([OH:17])[CH2:10]4)[CH2:28][O:29][C:24]=2[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 10760311HCID 10760311, compoundHCID 12095855HCID 12095855, compound

Product 1

HCID 102950998-{[(2s)-8-Methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}-3-(2-methoxyphenyl)-8-azabicyclo[3.2.1]octan-3-olYield 70%

Procedure

The title compound was prepared by the same procedure described in Example 1, Step 4 using 3-(2-methoxyphenyl)-8-azabicyclo[3.2.1]octan-3-ol in place of 3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]octan-3-ol, and (S)-toluene-4-sulfonic acid 8-methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester in place of (S)-toluene-4-sulfonic acid 8-ethoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester. Yield: 70%, white solid.

Sources & evidence

ORD record
ord-70dced61c7c746b2bc862a0e40ef54db
Source dataset
uspto-grants-2003_12
Patent number
US06656951B2

Reaction notes

Loading…