HCID 10760311, compound → HCID 9846538, compound

HRID 431002Notes

Reaction equation

HRID 431002 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([C:9]2([OH:17])[CH2:15][CH:14]3[NH:16][CH:11]([CH2:12][CH2:13]3)[CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH3:20][O:21][C:22]1[C:27]2[O:28][C@H:29]([CH2:32]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:30][O:31][C:26]=2[CH:25]=[CH:24][CH:23]=1>>[CH3:20][O:21][C:22]1[C:27]2[O:28][C@@H:29]([CH2:32][N:16]3[CH:11]4[CH2:12][CH2:13][CH:14]3[CH2:15][C:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:18])[F:19])[CH:4]=3)([OH:17])[CH2:10]4)[CH2:30][O:31][C:26]=2[CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 10760311HCID 10760311, compoundHCID 130912563-(3-Trifluromethylphenyl)-8-azabicyclo[3.2.1]octan-3-ol

Product 1

HCID 9846538HCID 9846538, compoundYield 68%

Procedure

The title compound was prepared by the same procedure described in Example 1, Step 4 using 3-(3-trifluromethylphenyl)-8-azabicyclo[3.2.1]octan-3-ol in place of 3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]octan-3-ol, and (S)-toluene-4-sulfonic acid 8-methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester in place of (S)-toluene-4-sulfonic acid 8-ethoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester. Yield: 68%, white solid.

Sources & evidence

ORD record
ord-f072ce6a5a7347d68bcfd72e216f2c92
Source dataset
uspto-grants-2003_12
Patent number
US06656951B2

Reaction notes

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