HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10760311, compound → 8-{[(2s)-8-Methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}-3-(2-pyridinyl)-8-azabicyclo[3.2.1]octan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10760311 | HCID 10760311 | — |
| Reactant | HCID 12095854 | HCID 12095854 | — |
| Product | 8-{[(2s)-8-Methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}-3-(2-pyridinyl)-8-azabicyclo[3.2.1]octan-3-ol | HCID 10293263 | 70% |
Reaction Steps
The title compound was prepared by the same procedure described in Example 1, Step 4 using 3-(2-pyridinyl)-8-azabicyclo[3.2.1]octan-3-ol in place of 3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]octan-3-ol, and (S)-toluene-4-sulfonic acid 8-methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester in place of (S)-toluene-4-sulfonic acid 8-ethoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester. Yield: 70%, white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06656951B2 |
| Source dataset | uspto-grants-2003_12 |
| ORD ID | ord-e32eea23180240f0a9684c676ca4f527 |
| Source note | uspto-grants-2003_12 |