HCID 10760311, compound → HCID 10293207, compound

HRID 431005Notes

Reaction equation

HRID 431005 reaction equation
[C:1]1([C:7]2([OH:15])[CH2:13][CH:12]3[NH:14][CH:9]([CH2:10][CH2:11]3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][O:17][C:18]1[C:23]2[O:24][C@H:25]([CH2:28]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:26][O:27][C:22]=2[CH:21]=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[C:23]2[O:24][C@@H:25]([CH2:28][N:14]3[CH:9]4[CH2:10][CH2:11][CH:12]3[CH2:13][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([OH:15])[CH2:8]4)[CH2:26][O:27][C:22]=2[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 10760311HCID 10760311, compoundHCID 130912463-Phenyl-8-azabicyclo[3.2.1]octan-3-ol

Product 1

HCID 10293207HCID 10293207, compoundYield 76%

Procedure

The title compound was prepared by the same procedure described in Example 1, Step 4 using 3-phenyl-8-azabicyclo[3.2.1]octan-3-ol in place of 3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]octan-3-ol, and (S)-toluene-4-sulfonic acid 8-methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester in place of (S)-toluene-4-sulfonic acid 8-ethoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester. Yield: 76%, white solid.

Sources & evidence

ORD record
ord-dc1c3c7a7d794826a9fff1c335e59123
Source dataset
uspto-grants-2003_12
Patent number
US06656951B2

Reaction notes

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