6-(4-Methylpiperazin-1-yl)pyridin-3-amine → HCID 44516609, compound

HRID 43101Notes

Reaction equation

HRID 43101 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:17]=1[C:23]1[C:32]2[N:31]=[CH:30][CH:29]=[N:28][C:27]=2[C:26]([C:33](O)=[O:34])=[CH:25][CH:24]=1>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH:14][C:33]([C:26]3[C:27]4[N:28]=[CH:29][CH:30]=[N:31][C:32]=4[C:23]([C:17]4[C:18]([CH3:22])=[CH:19][CH:20]=[CH:21][C:16]=4[CH3:15])=[CH:24][CH:25]=3)=[O:34])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 27633906-(4-Methylpiperazin-1-yl)pyridin-3-amineHCID 669145748-(2,6-Dimethyl-phenyl)quinoxaline-5-carboxylic acid

Product 1

HCID 44516609HCID 44516609, compound

Procedure

The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture for 20 h at rt, using 6-(4-methylpiperazin-1-yl)-pyridin-3-ylamine (prepared as described in Example 33 but using N-methyl-piperazine in Step 33.2) and 8-(2,6-dimethyl-phenyl)-quinoxaline-5-carboxylic acid (Example 71). Title compound: ESI-MS: 453.1 [M+H]+; tR=3.55 min (System 1).

Workup

  1. customThe title compound was prepared in analogy to the procedure

Sources & evidence

ORD record
ord-a37cf6ce17304defba234e4b2f1c95a8
Source dataset
uspto-grants-2013_09
Patent number
US08536175B2

Reaction notes

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