Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | MeOH tetrahydrofuran | HCID 21899815 | — |
| Reactant | 8-(2,6-Dimethyl-phenyl)quinoxaline-5-carboxylic acid | HCID 66914574 | — |
| Reactant | HCID 178480844 | HCID 178480844 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178424773 | HCID 178424773 | — |
Reaction Steps
The title compound was prepared in analogy to the procedures described in Example 14 but stirring the reaction mixture for at 60° C. overnight, using 1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine (Step 20.1) instead of 2-nitroimidazole in Step 14.3 and 8-(2,6-dimethylphenyl)-quinoxaline-5-carboxylic acid (Example 71), and using Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2. Title compound: ESI-MS: 456.1 [M+H]+; tR=3.18 min (System 1); TLC: Rf=0.15 (DCM/MeOH, 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08536175B2 |
|---|
| Source dataset | uspto-grants-2013_09 |
|---|
| ORD ID | ord-e248b287c12545c5bcfaf8d7e0484aaa |
|---|
| Source note | uspto-grants-2013_09 |
|---|
